Managing Organ Dysfunction and Failure: A Guide for ACCS Trainees
Executive Summary
The effective management of organ dysfunction and failure is a cornerstone of Emergency and Critical Care Medicine. This briefing document outlines the essential knowledge and procedural steps for ACCS trainees to achieve competence and excel in this critical domain, corresponding to RCEM curriculum code ACCS LO 3 / SLO 1.
Key takeaways include the imperative to recognize impending organ failure before physiological decompensation by looking beyond vital signs and utilizing tools like NEWS2 and lactate trends. A structured, critical-care-focused Airway, Breathing, Circulation, Disability, Exposure (A-E) assessment is paramount. This involves anticipating the need for advanced airway management, differentiating respiratory failure types, defining shock states with the aid of Point of Care Ultrasound (POCUS), and initiating neuroprotective measures.
Initial management focuses on timely organ support. Cardiovascular support requires judicious fluid challenges with balanced crystalloids, followed by the early initiation of peripheral vasopressors to maintain a Mean Arterial Pressure (MAP) > 65mmHg. Respiratory support involves escalating from standard oxygen to High-Flow Nasal Oxygen (HFNO) or Non-Invasive Ventilation (NIV) where appropriate, with a low threshold for recognizing treatment failure. Renal protection is achieved through strict fluid balance, maintaining perfusion, and ceasing nephrotoxic medications.
Excellence in this area transcends basic management; it involves advanced physiological reasoning, such as understanding fluid responsiveness versus tolerance and calculating the Shock Index. Furthermore, superior performance is demonstrated through strong team leadership, employing closed-loop communication, developing a shared mental model, and making timely, appropriate decisions regarding escalation to Critical Care or establishing a ceiling of care.
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Introduction
The ability to recognize, stabilize, and manage patients presenting with organ dysfunction is a fundamental requirement for trainees in Acute Care Common Stem (ACCS) and Emergency Medicine. This learning outcome demands more than a routine assessment; it requires a deep understanding of pathophysiology, the skills to initiate organ support, and the nuanced decision-making involved in escalating care to the Intensive Care Unit (ICU). This guide provides a structured approach to developing these capabilities, from initial assessment to advanced management strategies and portfolio development.
Recognition and Systematic Clinical Assessment
The first and most critical step in managing organ failure is its early recognition, often before the patient exhibits overt signs of decompensation.
Identifying the 'At-Risk' Patient
Physiological compensation can effectively mask profound underlying organ dysfunction, leading to a sudden and catastrophic decline known as the "physiological cliff." Therefore, assessment must go beyond simple vital signs.
- Early Warning Scores: The National Early Warning Score (NEWS2) should be used to track physiological trends over time. It serves as a crucial trigger for review, not as a standalone diagnostic tool (1).
- Biochemical Markers: Serum lactate is a key surrogate marker for tissue hypoperfusion. A rising lactate level, particularly in a patient undergoing resuscitation, is a significant indicator of ongoing microvascular failure and inadequate resuscitation.
The Structured A-E Assessment: A Critical Care Focus
The standard A-E assessment must be adapted with a critical care mindset to identify and pre-empt organ failure.
- Airway: Assess for patency, protection, and the potential for future deterioration.
- Excellence Point: Anticipate the need for Rapid Sequence Induction (RSI) early. If a patient shows signs of tiring, has a dropping Glasgow Coma Scale (GCS), or is failing to protect their airway, an immediate call to Anaesthetics/ICU is warranted.
- Breathing: Differentiate between Type 1 (Hypoxic) and Type 2 (Hypercapnic) respiratory failure to guide therapy.
- Intervention: Promptly escalate respiratory support from a non-rebreather mask to High Flow Nasal Oxygen (HFNO) or Non-Invasive Ventilation (NIV) when indicated (2).
- Circulation: The primary goal is to define the shock state. Classify the shock as Distributive, Cardiogenic, Hypovolaemic, or Obstructive to direct treatment.
- Excellence Point: Utilize Point of Care Ultrasound (POCUS) to dynamically assess fluid status (e.g., IVC diameter and collapsibility) and cardiac contractility. This prevents the harm associated with administering large fluid volumes to a patient with a failing heart (3).
- Disability: Perform a rapid neurological assessment, including checking blood glucose and pupillary response.
- Intervention: In patients with brain injuries, institute neuroprotective measures by maintaining normoglycaemia and avoiding pyrexia.
- Exposure: Conduct a full top-to-toe examination to identify potential sources of sepsis (e.g., skin infections, lines), rashes suggestive of specific pathologies, or evidence of trauma.
Step-by-Step Management and Organ Support
Demonstrating competence requires the ability to safely and effectively initiate organ support in the Emergency Department.
Step 1: Cardiovascular Support
While fluid resuscitation is the initial step, it must be administered cautiously to avoid the significant harm associated with fluid overload.
- Fluid Challenge: Administer a bolus of 250-500ml of a balanced crystalloid solution (e.g., Plasmalyte, Hartmann’s). Systematically assess the patient's response by monitoring blood pressure, heart rate, capillary refill time, and urine output.
- Vasopressor Initiation: If hypotension persists after initial fluid resuscitation, vasopressors should be started early to restore organ perfusion. The target is a Mean Arterial Pressure (MAP) of >65mmHg (4).
- Medication: Peripheral vasopressors such as Metaraminol or a dilute Noradrenaline infusion can be used.
- Safety Precaution: Administration requires a patent, large-bore cannula in a large, proximal vein. The site must be checked frequently for any signs of extravasation.
Step 2: Respiratory Support
- Oxygen Saturation Targets: Aim for SpO2 of 94-98% in most patients. For patients at risk of hypercapnic respiratory failure (e.g., COPD), the target should be 88-92%.
- High Flow Nasal Oxygen (HFNO): This is an excellent intervention for Type 1 respiratory failure (e.g., pneumonia). HFNO delivers a high flow of humidified, heated oxygen, which provides a degree of Positive End-Expiratory Pressure (PEEP) and reduces anatomical dead space (2).
- Non-Invasive Ventilation (NIV):
- CPAP: Continuous Positive Airway Pressure is the first-line treatment for acute cardiogenic pulmonary oedema.
- BiPAP: Bilevel Positive Airway Pressure is the first-line treatment for exacerbations of COPD with respiratory acidosis.
- Excellence Point: Recognize NIV failure early. Signs of failure include patient agitation, significant air leak, or a failure of the pH to improve after one hour of therapy. If failure is recognized, plans for definitive airway management (intubation) must be made immediately.
Step 3: Renal Protection
Acute Kidney Injury (AKI) is a common complication of critical illness and is independently associated with increased mortality.
- Monitoring: An indwelling urinary catheter is mandatory for strict fluid balance monitoring.
- Perfusion: Maintain adequate renal perfusion pressure by ensuring the MAP remains >65mmHg.
- Medication Review: Stop all nephrotoxic drugs, including ACE inhibitors, NSAIDs, and certain antibiotics like Gentamicin.
- Managing Complications: Treat hyperkalaemia immediately. Administer intravenous Calcium Gluconate for cardiac membrane stabilization, followed by an Insulin/Dextrose infusion to shift potassium intracellularly.
Strategies for Excelling in Practice
Moving from competence to excellence involves a deeper understanding of physiology, team dynamics, and system-level management.
Advanced Physiological Reasoning
- Fluid Responsiveness vs. Fluid Tolerance: A key concept is that while a patient may be "fluid responsive" (i.e., their stroke volume increases with a fluid bolus), this does not automatically mean they require more fluid. Additional fluid should only be given if there is concurrent clinical evidence of hypoperfusion.
- Shock Index (SI): Calculate the SI by dividing the Heart Rate by the Systolic Blood Pressure (HR/SBP). An SI greater than 0.9 is a strong indicator of significant shock, even if the blood pressure appears deceptively normal (5).
Human Factors and Team Leadership
- Closed-Loop Communication: When leading a resuscitation, ensure all instructions are heard, understood, and actioned. The team member should repeat the instruction back, and the leader should receive confirmation once the task is complete.
- Shared Mental Model: Verbalize the clinical picture, the team's actions, and the treatment goals. For example: "This is a 65-year-old with septic shock. We have given 2L of fluid and are starting Metaraminol. The target MAP is 65." This ensures the entire team is aligned.
Appropriate Escalation and De-escalation
- Ceiling of Care: Initiate discussions about the appropriate level of intervention and potential "ceiling of care" early in the patient's journey, involving patients and relatives where possible. Excellence includes knowing when resuscitation is not appropriate.
- ICU Consultation: Consult the Intensive Care team early. Present the case clearly and concisely using a structured handover tool like SBAR (Situation, Background, Assessment, Recommendation).
- Definitive Care: Do not delay the patient's transfer to definitive care, whether that is the cardiac catheterization lab, the operating theatre, or the ICU.
Achieving the Learning Outcome: Portfolio Evidence
To demonstrate achievement of this ACCS learning outcome, trainees must provide robust evidence within their ePortfolio.
Expected Capabilities and Descriptors
Trainees are expected to demonstrate the ability to:
- Recognise, assess, and initiate management for acutely ill adults with single or multiple organ failure.
- Recognise and manage sepsis, employing local infection control policies.
- Safely perform invasive procedures for cardiovascular, renal, and respiratory support.
- Utilise and interpret laboratory and imaging investigations.
- Manage ongoing medical needs and organ support, including holistic care for patients and relatives.
- Recognise the limitations of intensive care and apply appropriate admission criteria.
- Plan and communicate patient discharge from intensive care effectively.
- Support end-of-life care within the ICU environment.
- Understand the role of transplant services and the principles of brain-stem death testing.
- Support staff outside the ICU in the early detection of deteriorating patients.
Generating Portfolio Evidence
Evidence to inform entrustment decisions can be gathered through various workplace-based assessments and activities:
- Case-based Discussion (CbD): Discuss a complex case, such as septic shock or diabetic ketoacidosis, focusing on the rationale for fluid management strategies and choices of vasoactive drugs.
- Mini-Clinical Evaluation Exercise (Mini-CEX): Arrange for a consultant to directly observe the leadership of a resuscitation case or the practical skill of setting up and managing NIV.
- Reflection: Provide written reflections on challenging cases. Examples include a difficult communication with the ICU team or a case where a decision was made for palliative care.
- Other Evidence: Multi-Source Feedback (MSF) and the Multi-Consultant Report (MCR) will also contribute to the overall assessment.
- RCEMLearning Resources: Utilize modules, Single Best Answer (SBA) questions, and Short Answer Questions (SAQ) from the RCEMLearning platform relevant to this learning outcome. Certificates of completion are automatically added to the CPD Diary and provide excellent evidence of engagement.
References
- Royal College of Physicians. National Early Warning Score (NEWS) 2: Standardising the assessment of acute-illness severity in the NHS. Updated report of a working party. London: RCP; 2017.
- Rochwerg B, Einav S, Chaudhuri D, Mancebo J, Mauri T, Helviz Y, et al. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline. Intensive Care Med. 2020;46(12):2226-2237.
- Working Group on Ultrasound in Acute Care Medicine. International evidence-based recommendations for point-of-care lung ultrasound. Intensive Care Med. 2012;38(4):577-591.
- Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Crit Care Med. 2021;49(11):e1063-e1143.
- Allgöwer M, Burri C. Shock index. Dtsch Med Wochenschr. 1967;92(43):1947-1950.